In the "Academics" persona you have the option to enroll a group of students into a course all at once. You should also be able to "bulk withdraw" a group of students from a course all at once. This would be useful in case you accidentally enroll a group in the wrong course or if your school's plans change and suddenly students of a certain grade aren't supposed to take that course.
I wouldn't limit this to just Academics. I would like to see this for Advisory Groups and Community Groups as well. It could even be an upload option, but just something more than having to remove everyone manually.
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